PROCESS FOR PRODUCING OPTICALLY ACTIVE PENEMES

Processes for the preparation of a penem derivative of formula I I wherein n=0 or 1; R is a carboxy protecting group or H; R1 is hydrogen, a hydrocarbon group substituted or unsubstituted, or lower alkoxy; and R2 is hydrogen, C1-C5 alkyl, carbamoyl N-substituted by lower alkyl or unsubstituted, or a...

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Bibliographische Detailangaben
Hauptverfasser:	BATTISTINI,CARLO,IT, LAPEGIANI,MARCO,IT, FOGLIO,MAURIZIO,IT, ZARINI,FRANCO,IT, FRANCESCHI,GIOVANNI,IT, BEDESCHI,ANGELO,IT
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Processes for the preparation of a penem derivative of formula I I wherein n=0 or 1; R is a carboxy protecting group or H; R1 is hydrogen, a hydrocarbon group substituted or unsubstituted, or lower alkoxy; and R2 is hydrogen, C1-C5 alkyl, carbamoyl N-substituted by lower alkyl or unsubstituted, or an acyl group; and the pharmaceutically acceptable salts thereof. These processes allow one to prepare stereospecifically only 5R derivatives, and are characterized by R2-introduction at a very late stage in the synthesis, thereby enabling a great number of compounds of formula I to be prepared. Penem derivatives are useful antibacterial agents.