PROCESS FOR PRODUCING /E/ -5-/2-BROMOVINYL/-2-COMMA ABOVE-DEOXYURIDINE AND O-ACYL DERIVATIVES
(E)-5-(2-bromovinyl)-2'- deoxyuridine and its derivatives of general formula VI (where R is H or as defined below) are prepared from 3,5'-di-O-acyl-5-ethyl- 2'-deoxyuridines of general formula IV (wherein R is C1-8 alkanoyl, benzoyl or benzoyl group substituted in para position by C1-...
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| creator | RATONYI,ZOLTAN,HU VOEROESHAZY,LAJOS,HU BAERWOLF,DIETER,DD JUST,HELLMUT,DD REEFSCHLAEGER,JUERGEN,DD MRS TUEDOES,FERENCNE,HU GAL,TIBOR,HU MRS SZABOLCS,OTTONE,HU OETVOES,LASZLO,HU SAGI,JSOS,HU DAROCZY,IVAN,HU |
| description | (E)-5-(2-bromovinyl)-2'- deoxyuridine and its derivatives of general formula VI (where R is H or as defined below) are prepared from 3,5'-di-O-acyl-5-ethyl- 2'-deoxyuridines of general formula IV (wherein R is C1-8 alkanoyl, benzoyl or benzoyl group substituted in para position by C1-4 alkyl or halogen) by reaction with bromine to give a dibromo derivative of general formula V which is then dehydrohalogenated and if desired deacylated to give the compound of formula of formula (VI) in which R is H. The compounds of formula (VI) in which R is other than H are new compounds and are metabolic precursors for (E)-5-(2-bromovinyl-2'- deoxyuridine. These compounds are thus useful in medicine. |
| format | Patent |
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The compounds of formula (VI) in which R is other than H are new compounds and are metabolic precursors for (E)-5-(2-bromovinyl-2'- deoxyuridine. 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The compounds of formula (VI) in which R is other than H are new compounds and are metabolic precursors for (E)-5-(2-bromovinyl-2'- deoxyuridine. These compounds are thus useful in medicine.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS |
| title | PROCESS FOR PRODUCING /E/ -5-/2-BROMOVINYL/-2-COMMA ABOVE-DEOXYURIDINE AND O-ACYL DERIVATIVES |
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