PROCESS FOR PRODUCING /E/ -5-/2-BROMOVINYL/-2-COMMA ABOVE-DEOXYURIDINE AND O-ACYL DERIVATIVES

PROCESS FOR PRODUCING /E/ -5-/2-BROMOVINYL/-2-COMMA ABOVE-DEOXYURIDINE AND O-ACYL DERIVATIVES

(E)-5-(2-bromovinyl)-2'- deoxyuridine and its derivatives of general formula VI (where R is H or as defined below) are prepared from 3,5'-di-O-acyl-5-ethyl- 2'-deoxyuridines of general formula IV (wherein R is C1-8 alkanoyl, benzoyl or benzoyl group substituted in para position by C1-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: RATONYI,ZOLTAN,HU, VOEROESHAZY,LAJOS,HU, BAERWOLF,DIETER,DD, JUST,HELLMUT,DD, REEFSCHLAEGER,JUERGEN,DD, MRS TUEDOES,FERENCNE,HU, GAL,TIBOR,HU, MRS SZABOLCS,OTTONE,HU, OETVOES,LASZLO,HU, SAGI,JSOS,HU, DAROCZY,IVAN,HU
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:(E)-5-(2-bromovinyl)-2'- deoxyuridine and its derivatives of general formula VI (where R is H or as defined below) are prepared from 3,5'-di-O-acyl-5-ethyl- 2'-deoxyuridines of general formula IV (wherein R is C1-8 alkanoyl, benzoyl or benzoyl group substituted in para position by C1-4 alkyl or halogen) by reaction with bromine to give a dibromo derivative of general formula V which is then dehydrohalogenated and if desired deacylated to give the compound of formula of formula (VI) in which R is H. The compounds of formula (VI) in which R is other than H are new compounds and are metabolic precursors for (E)-5-(2-bromovinyl-2'- deoxyuridine. These compounds are thus useful in medicine.