PROCESS FOR PRODUCING 6,7-DIMETHOXY-5-AMINO-2-SQUARE BRACKET-4-BRACKET-2-FUROYL-BRACKET CLOSED-1-PIPERAZINYL-SQUARE BRACKET C.OSED-QUINAZOLINE HYDROCHLOKIKE

PROCESS FOR PRODUCING 6,7-DIMETHOXY-5-AMINO-2-SQUARE BRACKET-4-BRACKET-2-FUROYL-BRACKET CLOSED-1-PIPERAZINYL-SQUARE BRACKET C.OSED-QUINAZOLINE HYDROCHLOKIKE

An improved method is disclosed for producing antihypertensively active 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl] quinazoline hydrochloride, viz prazosine hydrochloride, by reacting methyl-N-(3,4-dimethoxy-6-cyano-phenyl)-[4-(2-furoyl)-1-piperazinyl]th ioformamidate with a large excess of...

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Bibliographische Detailangaben
Hauptverfasser: KOIVISTO,MAIJA,K.,FI, PIPPURI,AINO,K.,FI, THALER,HEINRICH,FI, KAIRISALO,PEKKA,J.,FI, HONKANEN,ERKKI,J.,FI, TUOMI,SIRPA,A.,FI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:An improved method is disclosed for producing antihypertensively active 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl] quinazoline hydrochloride, viz prazosine hydrochloride, by reacting methyl-N-(3,4-dimethoxy-6-cyano-phenyl)-[4-(2-furoyl)-1-piperazinyl]th ioformamidate with a large excess of ammonium chloride.