PROCESS FOR PRODUCING 6-THIA-TETRACYLIN DERIVATIVES

PROCESS FOR PRODUCING 6-THIA-TETRACYLIN DERIVATIVES

A process for the preparation of racemic 6-thiatetracycline derivatives comprises treating a mixture of epimers of corresponding 1,4,4a,5,5a,6,11,12a-octahydro-3,12-dihydroxy-1,11-dioxo-6-thianaphtha cene-2-carboxamides with a saturated heterocyclic secondary amine having a total of 4 to 12 carbon a...

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Bibliographische Detailangaben
1. Verfasser: KIRCHLECHNER,RICHARD,DE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A process for the preparation of racemic 6-thiatetracycline derivatives comprises treating a mixture of epimers of corresponding 1,4,4a,5,5a,6,11,12a-octahydro-3,12-dihydroxy-1,11-dioxo-6-thianaphtha cene-2-carboxamides with a saturated heterocyclic secondary amine having a total of 4 to 12 carbon atoms for a sufficient length of time at temperatures of about 15 DEG -120 DEG C.