PROCESS FOR PRODUCING NEW INTERMEDIATE FO 6,7-DIMETHOXY-4-AMINO-2-SQUARE BRACKET-4- BRACKET-2-FUROIYL-BRACKET CLOSED-1-PIPERAZINYL-SQUARE BRACKET CLOSED-QUINASOLINE OF OSED-1-PIPERAZINYL-SQUARE BRACKET CLOSED-QUINASOLINE OF

PROCESS FOR PRODUCING NEW INTERMEDIATE FO 6,7-DIMETHOXY-4-AMINO-2-SQUARE BRACKET-4- BRACKET-2-FUROIYL-BRACKET CLOSED-1-PIPERAZINYL-SQUARE BRACKET CLOSED-QUINASOLINE OF OSED-1-PIPERAZINYL-SQUARE BRACKET CLOSED-QUINASOLINE OF

Anovel benzonitrile, namely 3,4-dimethoxy-6-4-(2-furoyl)-1-piper-azinylthiocarbamide! benzonitrile is provided herein. It may be prepared by carrying out one of the following reaction, namely (a) reacting 3,4-dimethoxy-6-aminobenzonitrile having the formula (IV) with thiophosgene, to form 3,4-dimeth...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: HONKANEN,ERKKI J.,FI, PIPPURI,AINO K.,FI
Format: Patent
Sprache:eng ; hun
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Anovel benzonitrile, namely 3,4-dimethoxy-6-4-(2-furoyl)-1-piper-azinylthiocarbamide! benzonitrile is provided herein. It may be prepared by carrying out one of the following reaction, namely (a) reacting 3,4-dimethoxy-6-aminobenzonitrile having the formula (IV) with thiophosgene, to form 3,4-dimethoxy-6-isothiocyanatobenzonitrile having the formula (V) and then reacting compound (V) with 1-(2-furoyl)piperazine having the formula (VI) or (b) reacting 1-(2-furoyl)piperazine (Formula VI) with thiophosgene to form 4-(2-furoyl)-piperazinylthiocarbonyl chloride having the formula (VII ) and then reacting compound (VII) with 3,4-dimethoxy-6-amlnobenzonitrile(Formula (IV). The product is an intermediate in the production of the anthibypertensive drug prazosine by a process in which the formation of the quinazoline ring of prazosine occurs within the molecule.