PROCESS FOR PRODUCING INTERMEDIERS OF CEPH-3-EME-4-CARBOXYLIC ACIDS

PROCESS FOR PRODUCING INTERMEDIERS OF CEPH-3-EME-4-CARBOXYLIC ACIDS

A process is disclosed for the preparation of a compound of the formula I where R and R1 are defined herein below, wherein a compound of the structure; II is reacted in a suitable solvent with a haloamide in the presence of a metal oxide or a haloamide in the presence of a free radical initiator und...

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Bibliographische Detailangaben
Hauptverfasser: MASI,PAOLO,IT, BERNARDI,LUIGI,IT, FOGLIO,MAURIZIO,IT, SUARATO,ANTONINO,IT, PALAMIDESSI,GIORGIO,IT, FRANCESCHI,GIOVANNI,IT
Format: Patent
Sprache:eng ; hun
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process is disclosed for the preparation of a compound of the formula I where R and R1 are defined herein below, wherein a compound of the structure; II is reacted in a suitable solvent with a haloamide in the presence of a metal oxide or a haloamide in the presence of a free radical initiator under the influence of light or heat or alternatively with a halogen in the presence of a metal oxide, to give a compound of the structure; III which compound, in a suitable solvent is reacted with a suitable nucleophilic reagent to obtain the compound; IV which compound is then subjected to allylic halogenation to give a compound of the structure; V which is then reacted with a reducing agent to yield I.