5-THIA-1,4-DIAZABICYCLO (4.2.0.)OCTANE -3,8-DIOXO ANALOGS OF BETA-LACTAMS, THE PROCESS FOR THE PREPARATION AND USE THEREOF

5-THIA-1,4-DIAZABICYCLO (4.2.0.)OCTANE -3,8-DIOXO ANALOGS OF BETA-LACTAMS, THE PROCESS FOR THE PREPARATION AND USE THEREOF

Disclosed are novel 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo beta -lactam analogs of the general formula I wherein R is hydrogen or halo; R is hydrogen, halo, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCO-C6H4-CONH, isoxazolylcarboxamido; R is hydrogen, alkyl, benzyl, heterocycle, e.g. i...

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Bibliographische Detailangaben
Hauptverfasser: HERAK, JURE J, KOVA¯EVI}, MI}E, BRKI}, ZINKA, TOMI}, MIRJANA, MANDI}, ZORA, LUKI}, IRENA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed are novel 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo beta -lactam analogs of the general formula I wherein R is hydrogen or halo; R is hydrogen, halo, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCO-C6H4-CONH, isoxazolylcarboxamido; R is hydrogen, alkyl, benzyl, heterocycle, e.g. isoxazole, pyrazole etc., and n may be 1 or 2. They may be used as intermediates in preparing novel beta -lactam analogs or as active substances in formulations for antimicrobial therapy.