ANTIBODY-DRUG CONJUGATE LYOPHILISED FORMULATION

ANTIBODY-DRUG CONJUGATE LYOPHILISED FORMULATION

Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other simi...

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Bibliographische Detailangaben
Hauptverfasser: Valbjørn, Jesper, Jing, Xiaona, Paul, Timothy Warren, Willumsen, Bodil, Sacha, Gregory Allan, Pease, Nathan Alan, Roby, Kelly Ann
Format: Patent
Sprache:hrv ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.