CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO

CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO

In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted wit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Min, Ji Young, Park, Yun Hee, Lee, Soo Byung, Lee, In Su, Woo, Hyun Dong, Kim, Yong Zu, Kim, Min Sung, Chae, Jeiwook, Chung, Chul-Woong, Park, Kyung Eun, Oh, Yeong Soo, Kim, Jinyeong, Jun, Eun Ji, Choi, Hyo Jung, Kim, Hyoungrae, Song, Ho Young
Format: Patent
Sprache:hrv ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.