ACTIVIN-ACTRII ANTAGONISTS AND USES FOR TREATING MYELODYSPLASTIC SYNDROME

Provided herein is an activin-receptor type II (ActRII) signaling inhibitor for use in a method for treating anemia in a subject, wherein the method comprises administering a pharmaceutically effective dose of between 0.1 mg/kg and 2.0 mg/kg to the subject if the initial percentage of erythroblasts...

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Bibliographische Detailangaben
Hauptverfasser:	Laadem, Abderrahmane, Rovaldi, Christopher, Attie, Kenneth M
Format:	Patent
Sprache:	hrv ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	Provided herein is an activin-receptor type II (ActRII) signaling inhibitor for use in a method for treating anemia in a subject, wherein the method comprises administering a pharmaceutically effective dose of between 0.1 mg/kg and 2.0 mg/kg to the subject if the initial percentage of erythroblasts in the subject that are ring sideroblasts is at least 15%.