AN IMPROVED METHOD FOR HIGH LEVEL PRODUCTION OF CRM

AN IMPROVED METHOD FOR HIGH LEVEL PRODUCTION OF CRM

The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having an increased copy number of the CRM197 gene, wherein the method comprises growing the strain in media free of animal-derived components with one or...

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Bibliographische Detailangaben
Hauptverfasser: Sriraman, Rajan, Mantena, Narender Dev, Dixit, Mandar Shirish, Matur, Ramesh Venkat, Sureddi, Satyam Naidu, Chakka, Deviprasanna, Datla, Mahima, Masilamani, Balamurali
Format: Patent
Sprache:hrv ; eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having an increased copy number of the CRM197 gene, wherein the method comprises growing the strain in media free of animal-derived components with one or more amino acids.