HPV/CYAA-BASED CHIMERIC PROTEINS AND THEIR USES IN THE INDUCTION OF IMMUNE RESPONSES AGAINST HPV INFECTION AND HPV-INDUCED DISORDERS

HPV/CYAA-BASED CHIMERIC PROTEINS AND THEIR USES IN THE INDUCTION OF IMMUNE RESPONSES AGAINST HPV INFECTION AND HPV-INDUCED DISORDERS

The invention relates to a chimeric protein comprising or consisting of, from N-terminal to C-terminal, (a) a N-terminal part of a Bordetella CyaA protein (b) a heterologous polypeptide comprising antigens originating from different HPVs, and (c) a C-terminal part of a Bordetella CyaA protein. The i...

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Bibliographische Detailangaben
Hauptverfasser: Goubier, Anne, Misseri, Yolande, Bridonneau, Philippe
Format: Patent
Sprache:hrv ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to a chimeric protein comprising or consisting of, from N-terminal to C-terminal, (a) a N-terminal part of a Bordetella CyaA protein (b) a heterologous polypeptide comprising antigens originating from different HPVs, and (c) a C-terminal part of a Bordetella CyaA protein. The invention also relates to a polynucleotide encoding this chimeric protein. A composition comprising at least one chimeric protein(s) of the invention and the prophylactic and/or therapeutic uses of said composition are also part of the invention.