TETRAHYDROIMIDAZO[1,5-D][1,4]OXAZEPINE DERIVATIVE

A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof works as an mGluR2 antagonist, and is applicable as a therapeutic agent for neurological disorders related to glutamate dysfunction and diseases involving the mGluR2, such as Alzheimer's disease: w...

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Hauptverfasser: Sato, Nobuhiro, Braunton, Alan, Sasaki, Takeo, Motoki, Takafumi, Takahashi, Yoshinori, Takaishi, Mamoru, Shibuguchi, Tomoyuki
Format: Patent
Sprache:hrv ; eng
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Zusammenfassung:A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof works as an mGluR2 antagonist, and is applicable as a therapeutic agent for neurological disorders related to glutamate dysfunction and diseases involving the mGluR2, such as Alzheimer's disease: wherein R is a hydrogen atom, a C 1-6 alkyl group or the like, R 1 is a C 1-6 alkyl group, a C 1-6 alkoxy group or the like, R 2 is a halogen atom, a C 1-6 alkyl group, a C 1-6 alkoxy group or the like, R 3 is a hydrogen atom, a C 1-6 alkyl group or the like, and R 4 is a C 1-6 alkyl group or the like.