BORONATES AS ARGINASE INHIBITORS
Compounds according to Formula I are potent inhibitors of Arginase I and II activity:where R1, R2, R3, R4, D, W, X, Y, and Z are defined in the specification. The invention also provides pharmaceutical compositions of the compounds and said compounds for use in treating or preventing cancer or a dis...
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| creator | Van Zandt, Michael Jagdmann, Gunnar Erik |
| description | Compounds according to Formula I are potent inhibitors of Arginase I and II activity:where R1, R2, R3, R4, D, W, X, Y, and Z are defined in the specification. The invention also provides pharmaceutical compositions of the compounds and said compounds for use in treating or preventing cancer or a disease or a condition associated with expression or activity of arginase I, arginase II or a combination thereof. |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | BORONATES AS ARGINASE INHIBITORS |
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