BORONATES AS ARGINASE INHIBITORS

BORONATES AS ARGINASE INHIBITORS

Compounds according to Formula I are potent inhibitors of Arginase I and II activity:where R1, R2, R3, R4, D, W, X, Y, and Z are defined in the specification. The invention also provides pharmaceutical compositions of the compounds and said compounds for use in treating or preventing cancer or a dis...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Van Zandt, Michael, Jagdmann, Gunnar Erik
Format: Patent
Sprache:hrv ; eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Compounds according to Formula I are potent inhibitors of Arginase I and II activity:where R1, R2, R3, R4, D, W, X, Y, and Z are defined in the specification. The invention also provides pharmaceutical compositions of the compounds and said compounds for use in treating or preventing cancer or a disease or a condition associated with expression or activity of arginase I, arginase II or a combination thereof.