SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES

The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N-R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MD...

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Bibliographische Detailangaben
Hauptverfasser:	HOLZER, PHILIPP, REN, HAIXIA, HERGOVICH LISZTWAN, JOANNA, BUSCHMANN, NICOLE, MASUYA, KEIICHI, PISSOT SOLDERMANN, CAROLE, KALLEN, JOERG, FURET, PASCAL, STUTZ, STEFAN, GESSIER, FRANÇOIS, BERGHAUSEN, JOERG, JACOBY, EDGAR
Format:	Patent
Sprache:	hrv ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N-R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.