5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS

Spoj, naznačen time što je 3-[3-tert-butilsulfanil-1-[4-(6-etoksipiridin-3-il)benzil]-5-(5-metilpiridin-2-ilmetoksi)-1H-indol-2-il]-2,2-dimetilpropionska kiselina, ili njezina farmaceutski prihvatljiva sol, farmaceutski prihvatljiv N-oksid ili farmaceutski prihvatljivi solvat. Patent sadrži još 28 p...

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Hauptverfasser:	JASMINE ELEANOR ZUNIC, NICHOLAS SIMON STOCK, JEFFREY ROGER ROPPE, MUSTAPHA HADDACH, JILLIAN F. EVANS, BRIAN ANDREW STEARNS, YIWEI LI, JOHN H. HUTCHINSON, PETPIBOON PEPPI PRASIT, JEANNIE M. ARRUDA, MARK MORAN
Format:	Patent
Sprache:	hrv ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	Spoj, naznačen time što je 3-[3-tert-butilsulfanil-1-[4-(6-etoksipiridin-3-il)benzil]-5-(5-metilpiridin-2-ilmetoksi)-1H-indol-2-il]-2,2-dimetilpropionska kiselina, ili njezina farmaceutski prihvatljiva sol, farmaceutski prihvatljiv N-oksid ili farmaceutski prihvatljivi solvat. Patent sadrži još 28 patentnih zahtjeva. Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.