PROCESS FOR THE PREPARATION OF DROSPIRENONE
Postupak priprave 6?,7?,15?,16?-dimetilen-3-oksi-17α-pregn-4-en-21,17-karbolaktona (I), naznačen time da obuhvaća sljedeće korake: 1) reakcija spoja 66sa spojem formule II:IIu kojoj je X halogen, a R- je -CH2-ORI, pri čemu je RI jedna od sljedećih zaštitnih skupina hidroksila: i) sililni derivat Q3S...
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| creator | ERIKA ANDRIOLO STEFANO RANCAN MAURO MONTORSI EDOARDO MARIANI |
| description | Postupak priprave 6?,7?,15?,16?-dimetilen-3-oksi-17α-pregn-4-en-21,17-karbolaktona (I), naznačen time da obuhvaća sljedeće korake: 1) reakcija spoja 66sa spojem formule II:IIu kojoj je X halogen, a R- je -CH2-ORI, pri čemu je RI jedna od sljedećih zaštitnih skupina hidroksila: i) sililni derivat Q3Si-, u kojem Q neovisno jedan od drugog predstavljaju (C1-C6)alkil, (C6-C10)aril, (C1-C4)alkilaril ili (C1-C4)alkoksiaril, ii) u kojoj n jest 1 ili 2; pri čemu je dobiven spoj 8:82) oksidacija spoja 8 s oksidansom zasnovanom na MnIV/VII uz uklanjanje skupine RI i time dobivanje drozpirenona I:Patent sadrži još 7 patentnih zahtjeva.
A process for the preparation of Drospirenone (I) according to the following scheme
wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing the formation of undesired side-products and is particularly convenient for industrial-scale manufacturing. |
| format | Patent |
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A process for the preparation of Drospirenone (I) according to the following scheme
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A process for the preparation of Drospirenone (I) according to the following scheme
wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing the formation of undesired side-products and is particularly convenient for industrial-scale manufacturing.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAOCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTcAnyDw7wDHL18_dz5WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8R5BAUYGhoYGhmYWISGGxsSpAgAiniZ3</recordid><startdate>20110430</startdate><enddate>20110430</enddate><creator>ERIKA ANDRIOLO</creator><creator>STEFANO RANCAN</creator><creator>MAURO MONTORSI</creator><creator>EDOARDO MARIANI</creator><scope>EVB</scope></search><sort><creationdate>20110430</creationdate><title>PROCESS FOR THE PREPARATION OF DROSPIRENONE</title><author>ERIKA ANDRIOLO ; STEFANO RANCAN ; MAURO MONTORSI ; EDOARDO MARIANI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HRP20110168TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>hrv ; eng</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>ERIKA ANDRIOLO</creatorcontrib><creatorcontrib>STEFANO RANCAN</creatorcontrib><creatorcontrib>MAURO MONTORSI</creatorcontrib><creatorcontrib>EDOARDO MARIANI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ERIKA ANDRIOLO</au><au>STEFANO RANCAN</au><au>MAURO MONTORSI</au><au>EDOARDO MARIANI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PREPARATION OF DROSPIRENONE</title><date>2011-04-30</date><risdate>2011</risdate><abstract>Postupak priprave 6?,7?,15?,16?-dimetilen-3-oksi-17α-pregn-4-en-21,17-karbolaktona (I), naznačen time da obuhvaća sljedeće korake: 1) reakcija spoja 66sa spojem formule II:IIu kojoj je X halogen, a R- je -CH2-ORI, pri čemu je RI jedna od sljedećih zaštitnih skupina hidroksila: i) sililni derivat Q3Si-, u kojem Q neovisno jedan od drugog predstavljaju (C1-C6)alkil, (C6-C10)aril, (C1-C4)alkilaril ili (C1-C4)alkoksiaril, ii) u kojoj n jest 1 ili 2; pri čemu je dobiven spoj 8:82) oksidacija spoja 8 s oksidansom zasnovanom na MnIV/VII uz uklanjanje skupine RI i time dobivanje drozpirenona I:Patent sadrži još 7 patentnih zahtjeva.
A process for the preparation of Drospirenone (I) according to the following scheme
wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing the formation of undesired side-products and is particularly convenient for industrial-scale manufacturing.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY STEROIDS |
| title | PROCESS FOR THE PREPARATION OF DROSPIRENONE |
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