NOVEL COMPOUNDS

Spoj formule (I) naznačen time da, R1 i R3 je isti ili različit, te je nezavisno odabran od H, (C1-C6) alkil, (C3-C7) cikloalkil, halo, CN, OF3, -O-(C1-C6)alkil, -CO2-(C1-C6)alkil, COOH, -CONH-(C1-C6)alkil, -CONH-aril, -NH2, -CONH-R6, The present invention discloses a novel thyroid like compounds of...

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Bibliographische Detailangaben
Hauptverfasser:	SHITALKUMAR PUKHARAJ ZAMBAD, ASHOK KASUNDRA, RAMESH GUPTA, M. AMIR SIDDIQUI, LAXMIKANT CHHIPA, DAVINDER TULI, VIJAY CHAUTHAIWALE, C. DUTT, SIRALEE MUNSHI, SUBRAT KUMAR BHATTAMISRA
Format:	Patent
Sprache:	hrv ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Spoj formule (I) naznačen time da, R1 i R3 je isti ili različit, te je nezavisno odabran od H, (C1-C6) alkil, (C3-C7) cikloalkil, halo, CN, OF3, -O-(C1-C6)alkil, -CO2-(C1-C6)alkil, COOH, -CONH-(C1-C6)alkil, -CONH-aril, -NH2, -CONH-R6, The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.