MULTI-PHASE CONTRACEPTIVE PREPARATION BASED ON A NATURAL ESTROGEN

Višefazni kontracepcijski pripravak zasnovan na prirodnom estrogenu sa sintetičkim gestagenom naznačen time, da se prva faza sastoji od dvije jedinice u okviru dnevne doze prirodnog estrogena estradiol valerata od 3 mg, druga faza se sastoji od dvije skupine jedinica u okviru dnevne doze, pri čemu se prva skupina sastoji od 5 jedinica u okviru dnevne doze u kombinaciji 2 mg estradiol valerata i najmanje dvostruke ili trostruke doze sintetičkog gestagena za sprečavanje ovulacije, dok se druga skupina sastoji od 17 jedinica u okviru dnevne doze u kombinaciji 2 mg estradiol valerata i najmanje trostruke ili četverostruke doze sintetičkog gestagena za sprečavanje ovulacije, treća faza sastoji se od 2 jedinice u okviru dnevne doze od 1 mg estradiol valerata, te se slijedeća faza sastoji od 2 jedinice u okviru dnevne doze farmaceutski neškodljivog placeba. Patent sadrži još 3 patentna zahtjeva. The multiphase preparation having higher contraceptive safety and reduced side effects is based on a combination of a natural oestrogen with dienogest or drospirenone. The multiphase preparation is characterized by a first phase consisting of 2 daily dose units of 3 mg of oestradiol valerate, a second phase consisting of 2 groups of daily dose units, wherein a first group is formed by 5 daily dose units each containing a combination of 2 mg of oestradiol valerate and at least two or three times an ovulation-inhibitory dose of dienogest or drospirenone and a second group is formed by 17 daily dose units each containing a combination of 2 mg of oestradiol valerate and at least three or four times the ovulation-inhibitory dose of dienogest or drospirenone, a third phase consisting of 2 daily dose units of 1 mg of oestradiol valerate, and a further phase consisting of 2 daily dose units of pharmaceutically acceptable placebo.