METHODS FOR IMPROVING BIOAVAILABILITY OF A RENIN INHIBITOR

Uporaba kombinacije inhibitora renina i inhibitora istjecanja proteina, pri čemu je inhibitor renina derivat amida δ-amino-γ-hidroksi-ω-aril-alkanoične kiseline ili njegova farmaceutski prihvatljiva sol, naznačena time, da se koristi za pripravu lijeka, pri čemu inhibitor istjecanja proteina poboljšava bioraspoloživost inhibitora renina, tepri čemu inhibitor istjecanja proteina je inhibitor MDR1. Patent sadrži još 29 patentnih zahtjeva. A pharmaceutical composition comprising a therapeutically effective amount of a renin inhibitor in combination with an efflux protein inhibitor, said efflux protein inhibitor being present in an amount such that, following administration, the bioavailability of a renin inhibitor is improved by at least 5%.