PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINES AS PDE 2 INHIBITORS

Spoj formule (I) i farmaceutski prihvatljive solispomenutih spojeva gdje su: R1 i R2 su vodik ili metoksi, a osigurano je da R1 i R2 nisu oba vodik ili oba metoksi; n je 1, 2, 3 ili 4; X je veza; O;S; C=O; -N(R)-, pri čemu R je vodik ili -(C1-C3)alkil; -C(OH)-; ili -SO2; aY je benzoksazolil; benzoti...

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Bibliographische Detailangaben
Hauptverfasser:	DAVID DUANE THOMPSON, ANDREW IAN MORRELL, THOMAS ARTHUR BEYER, ROBERT JAMES CHAMBERS, KELVIN LAM, MEI LI
Format:	Patent
Sprache:	hrv ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Spoj formule (I) i farmaceutski prihvatljive solispomenutih spojeva gdje su: R1 i R2 su vodik ili metoksi, a osigurano je da R1 i R2 nisu oba vodik ili oba metoksi; n je 1, 2, 3 ili 4; X je veza; O;S; C=O; -N(R)-, pri čemu R je vodik ili -(C1-C3)alkil; -C(OH)-; ili -SO2; aY je benzoksazolil; benzotiazolil; benzofurazanil; benzofuranil; benzotiadiazolil; benzisoksazolil; benzizotiazolil; benzimidazolil; piridil; isatinil; oksindolil; indazolil;indolil; fenil; tienil; ili furanil; gdje je Y eventualno neovisno supstituiran s jednim do tri radikala kao što su halogen; trifluormetil; metoksi; -C(=O)CH3; cijano; -C(CH3)2OH; -CH(CH3)OH; -CH(CF3)OH; -C(C=O)CF3; -SO2NH2; -C(=O)OCH3; -CH2COOH; tiazolil; ili oksadiazolil. Patent sadrži još 16 patentnih zahtjeva. The invention provides compounds of formula (I) prodrugs thereof, and the pharmaceutically acceptable salts of the compounds or prodrugs, wherein n, X, and Y are as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereof.