A PROCESS FOR THE PREPARATION OF {2-[4-(alpha-PHENYL-p-CHLORBENZYL)-PIPERAZIN-1-YL]ETHOXY} ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR

A PROCESS FOR THE PREPARATION OF {2-[4-(alpha-PHENYL-p-CHLORBENZYL)-PIPERAZIN-1-YL]ETHOXY} ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR

The invention refers to a novel process for the preparation of {2-[-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid, which comprises hydrolyzing an N,N-disubstituted {2-[-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetamide, wherein said substituents are selected from alkyl gr...

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Bibliographische Detailangaben
Hauptverfasser: PUTER TRINKA, NORBERT NUMETH, FERENC BARTHA, GYOERGY CLEMENTIS, GYULA SIMIG, KSLMSN NAGY, PSL VSGO, JOZSEF REITER, GYOERGYI VERECZKEYNU DONSTH, PUTER TOEMPE
Format: Patent
Sprache:eng
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Zusammenfassung:The invention refers to a novel process for the preparation of {2-[-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid, which comprises hydrolyzing an N,N-disubstituted {2-[-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetamide, wherein said substituents are selected from alkyl groups having 1 to 4 carbon atoms optionally substituted by a phenyl group, alkenyl groups having 2 to 4 carbon atoms or cyclohexyl groups, or the substituents together with the adjacent nitrogen atom of the acetoamido group, form a morpholino group.