PROCESS FOR THE PREPARATION OF THIAZOLIDINEDIONE DERIVATIVES

Postupak dobivanja 5-{4-[2-(N-metil-N-(2-piridil)amino)etoksi]benzil}-2,4-tiazolidindiona, ili njegovog tautomernog oblika ili njegove soli, ili njegovog solvata, gdje se navedeni postupak sastoji u katalitičkoj redukciji 5-{4-[2-(N-metil-N-(2-piridil)amino)etoksi]benziliden}-2,4-tiazolidindiona ili njegovog tautomernog oblika, ili njegovog solvata, naznačen time što se navedenu reakciju redukcije provodi uz upotrebu vodika pod tlakom većim od 1,379 × 105 Pa (20 psi); a zatim se, po potrebi, dobije farmaceutski prihvatljivu sol i/ili farmaceutski prihvatljiv solvat. Patent sadrži još 8 patentnih zahtjeva. A process for preparing a compound of formula (I): or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A represents a substituted or unsubstituted aromatic heterocyclyl group; R represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; A represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6, which process comprises catalytically reducing a compound of formula (II): wherein A , R , A and n are as defined in relation to formula (I), characterised in that the reduction reaction is carried out using a hydrogen pressure above 20psi; and thereafter if required forming a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I).