PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-CANCER COMPOUNDS

Postupak dobivanja spoja formule I: ili farmaceutski prihvatljive soli ili solvata navedenog spoja,gdje: svakog od R1 i R2 se neovisno bira između C1-C10 alkila i C1-C10 alkoksi, gdje navedeni alkili alkoksi su izborno supstituirani s do 2 supstituenta, koje se neovisno bira između hidroksi i C1-C6...

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Bibliographische Detailangaben
Hauptverfasser:	TYMOTHY NORRIS, RICHARD SHELTON LEHNER, DINOS PAUL SANTAFIANOS
Format:	Patent
Sprache:	hrv ; eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM AGRICULTURE ANIMAL HUSBANDRY APPARATUS THEREFOR BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FERROUS OR NON-FERROUS ALLOYS FISHING FORESTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PRETREATMENT OF RAW MATERIALS PRODUCTION AND REFINING OF METALS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING TREATMENT OF ALLOYS OR NON-FERROUS METALS
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Beschreibung
Zusammenfassung:	Postupak dobivanja spoja formule I: ili farmaceutski prihvatljive soli ili solvata navedenog spoja,gdje: svakog od R1 i R2 se neovisno bira između C1-C10 alkila i C1-C10 alkoksi, gdje navedeni alkili alkoksi su izborno supstituirani s do 2 supstituenta, koje se neovisno bira između hidroksi i C1-C6 alkoksi; R15 je H, C1-C10 alkil ili -(CH2)q(C6-C10 aril), gdje q je cijeli broj od 0 do 4; naznačen time što se sastoji u obradi spoja formule 2gdje R15, R1 i R2 su definirani gore, a G je blokirajuća skupina -C(OH)R3R4;svaki od R3 i R4 je neovisno C1-C6 alkil; s alkalnim metalom ili hidroksidom alkalnog metala, u otapalu kojeg čini hidroksi-supstituirani C1-C10 alkil. Patent sadrži još 12 patentnih zahtjeva. The present invention relates to methods and intermediates for preparing compounds of the formula 1 and the pharmaceutically acceptable salts and solvates thereof, as well as structurally related compounds, wherein R , R and R are as defined herein. The foregoing compounds are useful in the treatment of hyperproliferative disorders, such as cancers, in mammals. The present invention also relates to a method of preparing compounds of the formula 9 and the pharmaceutically acceptable salts and solvates thereof, wherein R -R and R are as defined herein.