SPIRO-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS

Compounds of the formula wherein A completes a 4 or 7 membered carbocyclic ring which may be saturated or mono-unsaturated and which may optionally be fused to a further saturated or unsaturated 5 or 6 membered carbocyclic ring; B is (CH2)m wherein m is an integer of from 1 to 3; each of R and R is independently H, C1-C6 alkyl, benzyl or an alternative biolabile ester-forming group; R is H or C1-C4 alkyl; R and R are each independently H, OH, C1-C4 alkyl or C1-C4 alkoxy; and R is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl(C2-C6 alkynyl), C3-C7 cycloalkyl, C3-C7 cycloalkenyl, C1-C6 alkoxy, -NR R , -NR COR , -NR SO2R or a saturated heterocyclic group; or C1-C6 alkyl substituted by one or more substituents chosen from halo, hydroxy, C1-C6 alkoxy, C2-C6 hydroxyalkoxy, C1-C6 alkoxy(C1-C6 alkoxy), C3-C7 cycloalkyl, C3-C7 cycloalkenyl, aryl, aryloxy, arlyoxy(C1-C4 alkoxy), heterocyclyl, heterocyclyloxy, -NR R , -NR COR , -NR SO2R , -CONR R , -SH, -S(O)pR , -COR or -CO2R ; wherein R and R are each independently H, C1-C4 alkyl, C3-C7 cycloalkyl (optionally substituted by hydroxy or C1-C4 alkoxy), aryl, aryl(C1-C4 alkyl), C2-C6 alkoxyalkyl, or heterocyclyl; or the two groups R and R are taken together with the nitrogen to which they are attached to form a pyrrolidinyl, piperidino, morpholino, piperazinyl or N-(C1-C4 alkyl)-piperazinyl group; R is H or C1-C4 alkyl; R is C1-C4 alkyl, CF3, aryl, aryl(C1-C4 alkyl), aryl(C1-C4 alkoxy), heterocycyl, C1-C4 alkoxy or NR R wherein R and R are as previously defined; R is C1-C4 alkyl, aryl, heterocyclyl or NR R wherein R and R are as previously defined; R is C1-C4 alkyl, C3-C7 cycloalkyl, aryl or heterocyclyl; R is H or C1-C4 alkyl; and p is 0, 1 or 2; or a pharmaceutically acceptable salts thereof or bioprecursor therefor are diuretic agents having utility in the treatment of hypertension, heart failure, renal insufficiency and in other disorders.