SCHISTOSOMICIDAL COMPOSITION COMPRISING OXAMNIQUINE AND PRAZIQUANTEL
Schistosomicidal compositions containing a compound of the formula:- wherein R and R each hydrogen, C1-C4 alkyl, hydroxy-C1-C4 alkyl, or C3-C6 cycloalkyl; R is nitro, cyano, fluorine, chlorine, bromine or iodine, and R is methyl or hydroxymethyl; or a pharmaceutically acceptable acid addition salt t...
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| creator | BRAMMER, KEITH WHITBY SHAW, JOHN RICHARDSON |
| description | Schistosomicidal compositions containing a compound of the formula:-
wherein R and R each hydrogen, C1-C4 alkyl, hydroxy-C1-C4 alkyl, or C3-C6 cycloalkyl;
R is nitro, cyano, fluorine, chlorine, bromine or iodine,
and R is methyl or hydroxymethyl;
or a pharmaceutically acceptable acid addition salt thereof;
and a compound of the formula:-
wherein R is cyclohexyl, 3-cyclohexenyl, 4-pyridyl, phenyl, 2-fluorophenyl or 4-aminophenyl, with or without a pharmaceutically acceptable diluent or carrier. Preferably, compound (I) is oxamniquine and compound (II) praziquantel. The compositions are unexpectedly active due to synergism.
Also described are methods of treating Schistosomiasis by the concomitant administration of compounds (I) and (II). |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_HK29585A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HK29585A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_HK29585A3</originalsourceid><addsrcrecordid>eNrjZHAJdvbwDA7xD_b39XT2dHH0UXD29w3wD_YM8fT3A7ODPIM9_dwV_CMcff08A0M9_VwVHP1cFAKCHKOAXEe_EFcfHgbWtMSc4lReKM3NIOvmGuLsoZtakB-fWlyQmJyal1oS7-FtZGlqYepoTEgeAGuiKwM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SCHISTOSOMICIDAL COMPOSITION COMPRISING OXAMNIQUINE AND PRAZIQUANTEL</title><source>esp@cenet</source><creator>BRAMMER, KEITH WHITBY ; SHAW, JOHN RICHARDSON</creator><creatorcontrib>BRAMMER, KEITH WHITBY ; SHAW, JOHN RICHARDSON</creatorcontrib><description>Schistosomicidal compositions containing a compound of the formula:-
wherein R and R each hydrogen, C1-C4 alkyl, hydroxy-C1-C4 alkyl, or C3-C6 cycloalkyl;
R is nitro, cyano, fluorine, chlorine, bromine or iodine,
and R is methyl or hydroxymethyl;
or a pharmaceutically acceptable acid addition salt thereof;
and a compound of the formula:-
wherein R is cyclohexyl, 3-cyclohexenyl, 4-pyridyl, phenyl, 2-fluorophenyl or 4-aminophenyl, with or without a pharmaceutically acceptable diluent or carrier. Preferably, compound (I) is oxamniquine and compound (II) praziquantel. The compositions are unexpectedly active due to synergism.
Also described are methods of treating Schistosomiasis by the concomitant administration of compounds (I) and (II).</description><edition>4</edition><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1985</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19850419&DB=EPODOC&CC=HK&NR=29585A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19850419&DB=EPODOC&CC=HK&NR=29585A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRAMMER, KEITH WHITBY</creatorcontrib><creatorcontrib>SHAW, JOHN RICHARDSON</creatorcontrib><title>SCHISTOSOMICIDAL COMPOSITION COMPRISING OXAMNIQUINE AND PRAZIQUANTEL</title><description>Schistosomicidal compositions containing a compound of the formula:-
wherein R and R each hydrogen, C1-C4 alkyl, hydroxy-C1-C4 alkyl, or C3-C6 cycloalkyl;
R is nitro, cyano, fluorine, chlorine, bromine or iodine,
and R is methyl or hydroxymethyl;
or a pharmaceutically acceptable acid addition salt thereof;
and a compound of the formula:-
wherein R is cyclohexyl, 3-cyclohexenyl, 4-pyridyl, phenyl, 2-fluorophenyl or 4-aminophenyl, with or without a pharmaceutically acceptable diluent or carrier. Preferably, compound (I) is oxamniquine and compound (II) praziquantel. The compositions are unexpectedly active due to synergism.
Also described are methods of treating Schistosomiasis by the concomitant administration of compounds (I) and (II).</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1985</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAJdvbwDA7xD_b39XT2dHH0UXD29w3wD_YM8fT3A7ODPIM9_dwV_CMcff08A0M9_VwVHP1cFAKCHKOAXEe_EFcfHgbWtMSc4lReKM3NIOvmGuLsoZtakB-fWlyQmJyal1oS7-FtZGlqYepoTEgeAGuiKwM</recordid><startdate>19850419</startdate><enddate>19850419</enddate><creator>BRAMMER, KEITH WHITBY</creator><creator>SHAW, JOHN RICHARDSON</creator><scope>EVB</scope></search><sort><creationdate>19850419</creationdate><title>SCHISTOSOMICIDAL COMPOSITION COMPRISING OXAMNIQUINE AND PRAZIQUANTEL</title><author>BRAMMER, KEITH WHITBY ; SHAW, JOHN RICHARDSON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HK29585A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1985</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BRAMMER, KEITH WHITBY</creatorcontrib><creatorcontrib>SHAW, JOHN RICHARDSON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRAMMER, KEITH WHITBY</au><au>SHAW, JOHN RICHARDSON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SCHISTOSOMICIDAL COMPOSITION COMPRISING OXAMNIQUINE AND PRAZIQUANTEL</title><date>1985-04-19</date><risdate>1985</risdate><abstract>Schistosomicidal compositions containing a compound of the formula:-
wherein R and R each hydrogen, C1-C4 alkyl, hydroxy-C1-C4 alkyl, or C3-C6 cycloalkyl;
R is nitro, cyano, fluorine, chlorine, bromine or iodine,
and R is methyl or hydroxymethyl;
or a pharmaceutically acceptable acid addition salt thereof;
and a compound of the formula:-
wherein R is cyclohexyl, 3-cyclohexenyl, 4-pyridyl, phenyl, 2-fluorophenyl or 4-aminophenyl, with or without a pharmaceutically acceptable diluent or carrier. Preferably, compound (I) is oxamniquine and compound (II) praziquantel. The compositions are unexpectedly active due to synergism.
Also described are methods of treating Schistosomiasis by the concomitant administration of compounds (I) and (II).</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SCHISTOSOMICIDAL COMPOSITION COMPRISING OXAMNIQUINE AND PRAZIQUANTEL |
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