DRUG CONJUGATES COMPRISING ANTIBODIES AGAINST CLAUDIN 18.2

DRUG CONJUGATES COMPRISING ANTIBODIES AGAINST CLAUDIN 18.2

The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cance...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WALTER, Korden, KREUZBERG, Maria, TÜRECI, Özlem, SAHIN, Ugur, MITNACHT-K RAUS, Rita, LE GALL, Fabrice, JACOBS, Stefan
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.