BORON-CONTAINING SMALL MOLECULES

This invention relates to boron-containing small molecules, specifically to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have propert...

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Bibliographische Detailangaben
Hauptverfasser:	LIKHOTVORIK, IGOR I, DIPIERRO, MICHAEL M, HERNANDEZ, VINCENT, S. VS, ZHANG, YONG-KANG, KENNEDY, ISAAC I, BENKOVIC, STEPHEN, J. SJ, STEMPHOSKI, AARON, M. AM, ZEGAR, SIEAD S, BAKER, STEPHEN, J. SJ, MAO, WEIMIN, AKAMA, TSUTOMU, PLATTNER, JACOB, J. JJ, SANDERS, VIRGINIA V, YIANNIKOUROS, GEORGE, PETROS GP, ZHOU, HUCHEN, HOLD, KARIN, M. KM, ALLEY, MICHAEL, RICHARD KEVIN MRK, MAPLES, KIRK, R. KR, ROCK, FERNANDO F
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	This invention relates to boron-containing small molecules, specifically to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.