NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK OF DEVELOPING SCOLIOSIS

NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK OF DEVELOPING SCOLIOSIS

Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also p...

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Bibliographische Detailangaben
Hauptverfasser: ELBAKRY, Mohamed M, AKOUME NDONG, Marie-Yvonne M-Y, MOREAU, Alain A
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Zusammenfassung:Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1γ tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1γ expression and/or activity.