CELL LINEAGE ASED IMMUNOGEN DESIGN WITH HUMANIZED ANIMALS

Non-human animals with humanized immunoglobulin loci and methods of using them in vaccine design are described, as well as methods for making broadly neutralizing antibodies against infectious agents and pathogens are provided. Non-human animals with humanized immunoglobulin loci used in B-cell-line...

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Bibliographische Detailangaben
Hauptverfasser:	John MCWHIRTER J, Andrew J. MURPHY AJ, Karolina A. MEAGHER KA, Aris I. BARAS AI, George D. YANCOPOULOS GD, Garnett KELSOE G, Israel LOWY I, Barton HAYNES B, Lynn MACDONALD L, Cagan GURER C
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR TRAPPING
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Beschreibung
Zusammenfassung:	Non-human animals with humanized immunoglobulin loci and methods of using them in vaccine design are described, as well as methods for making broadly neutralizing antibodies against infectious agents and pathogens are provided. Non-human animals with humanized immunoglobulin loci used in B-cell-lineage immunogen design in vaccine development are provided, as are methods of carrying out such design.