ANTIBODIES SPECIFIC FOR TROP-2 AND THEIR USES TROP-2

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to...

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Bibliographische Detailangaben
Hauptverfasser:	HO, WEI-HSIEN W-H, TRAN, THOMAS-TOAN TT, RAJPAL, ARVIND A, LIU, SHU-HUI S-H, STROP, PAVEL P, DORYWALSKA, MAGDALENA, GRAZYNA MG, SHELTON, DAVID, LOUIS DL
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.