NEUTRALISING ANTIBODIES TO THE MAJOR EXOTOXINS TCDA AND TCDB OF CLOSTRIDIUM DIFFICILE TCDA TCDB

This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.

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Bibliographische Detailangaben
Hauptverfasser:	J. E. COMPSON JE, A. C. PAYNE AC, D. E. O. KNIGHT DEO, D. P. HUMPHREYS DP, M. COX M, M. J. T. PAGE MJT, B. MACKENZIE B, D. J. LIGHTWOOD DJ, N. L. FISHER NL, K. J. M. HERVE KJM, K. L. TYSON KL
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.