NOVEL RUBELLA E1 ENVELOPE PROTEIN VARIANTS AND THEIR USE IN THE DETECTION OF ANTIRUBELLA ANTIBODIES E1

The invention relates to soluble rubella E1 antigens and variants of these antigens. The antigens contain amino acids 201 to 432 or 169 to 432 and are lacking amino acids 453 to 481 as well as at least the amino acids 143 to 164. They further contain a region spanning two disulfide-bridges. The inve...

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Bibliographische Detailangaben
Hauptverfasser:	SCHOLZ, CHRISTIAN, FAATZ, ELKE, ENGEL, ALFRED, UPMEIER, BARBARA, ZARNT, TORALF, BOLLHAGEN, RALF, SCHAARSCHMIDT, PETER
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The invention relates to soluble rubella E1 antigens and variants of these antigens. The antigens contain amino acids 201 to 432 or 169 to 432 and are lacking amino acids 453 to 481 as well as at least the amino acids 143 to 164. They further contain a region spanning two disulfide-bridges. The invention also relates to a recombinant DNA molecule encoding the rubella E1 antigens, the expression of rubella E1 antigens as chaperone fusion proteins and their use in a method of detecting antibodies against rubella in a sample.