MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS

MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS

Inhibitors of HCV of formula (I). and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; and n is 3, 4, 5, or 6; pharmaceutical compositions containing compounds...

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Bibliographische Detailangaben
Hauptverfasser: ANTONOV, DMITRY, SAMUELSSON, BENGT, BERTIL, RABOISSON, PIERRE, JEAN-MARIE, BERNARD, SIMMEN, KENNETH, ALAN, ROSENQUIST, AASA, ANNICA, KRISTINA, LINDSTROEM, MATS, STEFAN, NILSSON, KARL, MAGNUS, KAHNBERG, PIA, CECILIA, DE KOCK, HERMAN, AUGUSTINUS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Inhibitors of HCV of formula (I). and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; and n is 3, 4, 5, or 6; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I) are provided. Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.