ORAL OSMOTIC DOSAGE FORM HAVING A HIGH FLUX MEMBRANE

ORAL OSMOTIC DOSAGE FORM HAVING A HIGH FLUX MEMBRANE

Disclosed are oral osmotic dosage forms and methods wherein a semi-permeable membrane of the oral osmotic dosage form includes from about 23 wt % to about 50 wt % of a flux enhancer and from about 0.01 wt % to about 5 wt % of antioxidant, based on the total dry weight of the semi-permeable membrane....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BHATTI, GURDISH, SKLUZACEK, ROBERT, EDGREN, DAVID, E, LI, SHU
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed are oral osmotic dosage forms and methods wherein a semi-permeable membrane of the oral osmotic dosage form includes from about 23 wt % to about 50 wt % of a flux enhancer and from about 0.01 wt % to about 5 wt % of antioxidant, based on the total dry weight of the semi-permeable membrane. Such compositions provide high flux membranes with improved mechanical and transport stability during storage on the shelf.