2,4,5-TRISUBSTITUTED THIAZOLYL DERIVATIVES ANT THEIR ANTIINFLAMMATORY ACTIVITY

2,4,5-TRISUBSTITUTED THIAZOLYL DERIVATIVES ANT THEIR ANTIINFLAMMATORY ACTIVITY

This invention concerns the use of a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C1-6alkyl; C1-6alkyl substituted with hydroxy, carboxyl, cyano, amino, mono- or di(C1-6alkyl)amino,...

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Bibliographische Detailangaben
Hauptverfasser: DIELS, GASTON, STANISLAS, MARCELLA, VANDERMAESEN, NELE, DE BRABANDER, MARC, J, SIBLEY, ANTHONY, WILLIAM, NOULA, CATERINA, LOVE, CHRISTOPHER, JOHN, VAN WAUWE, JEAN. PIERRE, FRANS, COOYMANS, LUDWIG, PAUL, GONCHARENKO, MYKHAYLO, MOSES, ROGER, CLIVE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention concerns the use of a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C1-6alkyl; C1-6alkyl substituted with hydroxy, carboxyl, cyano, amino, mono- or di(C1-6alkyl)amino, aminocarbonyl, mono- or di(C1-6alkyl)aminocarbonyl, C1-6alkyloxycarbonyl or C1-6alkyloxy; polyhaloC1-4alkyl; C1-4alkyloxy; cyano; amino; aminocarbonyl; mono- or di(C1-6alkyl)aminocarbonyl; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; H2N-S(-O)2-; mono- or di(C1-6alkyl)amino-S(-O)2; -C(-N-Rx)NRyRz; Q is an optionally substituted carbocycle or an optionally substituted heterocycle; L is substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of diseases mediated through TNF-alpha and/or IL-12.