Anti-idiotype monoclonal antibodies, their use in active immunotherapy of malignant tumors and compositions containing them

Monoclonal anti-idiotype antibody which is specific for murine antibodies against gangliosides carrying N-glycolylated sialic acid particularly against those gangliosides which are expressed by tumoral cells. The monoclonal antibody is useful as immunomodulator for the treatment of cancer. Specifica...

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Hauptverfasser:	ELADIO IGLESIAS SIERRA, ANA MARIA VASQUEZ LOPEZ, ROLANDO PEREZ RODRIGUEZ, ALEXIS PEREZ GONZALEZ, IRENE BEAUSOLEIL DELGADO, GUMERSINDA BOMBINO LOPEZ
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Monoclonal anti-idiotype antibody which is specific for murine antibodies against gangliosides carrying N-glycolylated sialic acid particularly against those gangliosides which are expressed by tumoral cells. The monoclonal antibody is useful as immunomodulator for the treatment of cancer. Specifically, the monoclonal anti-idiotype antibody of the present invention is capable of inducing a response which is predominantly anti-idiotypic in xenogenic models. The monoclonal anti-idiotype antibody also exerts a protector effect against malignant tumors in animals