Process for the preparation of water-soluble camptothecin analogues as well as the compounds 10-hydroxy-11-c(1-6)- alkoxycamptothecin

Process for the preparation of water-soluble camptothecin analogues as well as the compounds 10-hydroxy-11-c(1-6)- alkoxycamptothecin

A process for the preparation of water soluble camptothecin analogs, including methods for the preparation of intermediates thereof, and the compounds prepared by said process. Water soluble camptothecin analogs are prepared which may be used for inhibiting the growth of tumor cells sensitive to suc...

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Bibliographische Detailangaben
Hauptverfasser: JEFFERY LEE WOOD, MARK MELLINGER, JOSEPH MARIAN FORTUNAK, ANTONIETTA ROSE MASTROCOLA, PATRICK LEE BURK
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A process for the preparation of water soluble camptothecin analogs, including methods for the preparation of intermediates thereof, and the compounds prepared by said process. Water soluble camptothecin analogs are prepared which may be used for inhibiting the growth of tumor cells sensitive to such analogs.