COMBINACIONES FARMACEUTICAS

LA PRESENTE INVENCION SE REFIERE A METODOS PARA TRATAR CONDICIONES PATOFISIOLOGICAS QUE IMPLICAN A LOS NEUTROFILOS, QUE COMPRENDEN ADMINISTRAR A UN PACIENTE QUE NECESITE TAL TRATAMIENTO UNA TERAPIA DE COMBINACION QUE COMPRENDE AL MENOS UN FACTOR INHIBIDOR DE LOS NEUTROFILOS (NIF) Y AL MENOS OTRO AGENTE QUE PROTEGE A LAS NEURONAS DE LA AGRESION TOXICA, INHIBE LA REACCION INFLAMATORIA DESPUES DE UNA LESION CEREBRAL O FAVORECE LA REPERFUSION CEREBRAL (ESTO ES, AGENTES NEUROPROTECTORES O TROMBOLITICOS/FIBRINOLITICOS), O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES. This invention relates, inter alia, to methods of treating pathophysiological conditions involving neutrophils, comprising administering to a patient in need of such treatment a combination therapy comprising at least one Neutrophil Inhibitory Factor (NIF) and at least one other agent that protects neurons from toxic insult, inhibits the inflammatory reaction after brain damage or promotes cerebral reperfusion (i.e. neuroprotective or thrombolytic/fibrinolytic agents), or a pharmaceutically acceptable salt thereof.