PROCESS FOR THE PREPARATION OF 2,2-DIMETHYL--(2,5-DIMETHYL-PHENOXY)-PENTANOIC ACID INTERMEDIATES FOR PREPARING THIS COMPOUND AND PROCESS FOR PREPARING THE INTERMEDIATES
Η εφεύρεση αφορά μια βελτιωμένη μέθοδο δια την παρασκευή 2, 2- διμεθυλ - 5 - (2, 5-διμεθυλοφαινοξυ)-πεντανοϊκού οξέος του τύπου (Ι)ω The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an este...
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Format: | Patent |
Sprache: | eng ; Greek |
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Zusammenfassung: | Η εφεύρεση αφορά μια βελτιωμένη μέθοδο δια την παρασκευή 2, 2- διμεθυλ - 5 - (2, 5-διμεθυλοφαινοξυ)-πεντανοϊκού οξέος του τύπου (Ι)ω
The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an ester of the general Formula (X) (X) wherein X represents halogen and Z stands for a straight or branched chain C1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group-with an alkali salt of 2,5-dimethylphenol of Formula (II) (II) or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. (XI) Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof. |
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