POROUS SILICA MICROSPHERES HAVING SILANOL-ENRICHED AND SILANIZED SURFACES

A chromatographic material having improved crush resistance and a high level of surface silanol groups comprises porous silica microspheres having an average diameter of about 0.5 to about 35 mu m, substantially all of said microspheres having a diameter ranging from about 0.5 to about 1.5 times sai...

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Bibliographische Detailangaben
Hauptverfasser:	KOEHLER, JUERGEN, KIRKLAND, JOSEPH JACK
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMPOUNDS THEREOF INORGANIC CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY NON-METALLIC ELEMENTS PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS TESTING THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	A chromatographic material having improved crush resistance and a high level of surface silanol groups comprises porous silica microspheres having an average diameter of about 0.5 to about 35 mu m, substantially all of said microspheres having a diameter ranging from about 0.5 to about 1.5 times said average diameter; said microspheres comprising a plurality of substantially uniform-size colloidal particles, having a silica surface, arranged in an interconnected three-dimensional lattice; said colloidal particles occupying less than about 50 volume percent of said microspheres with the remaining volume being occupied by interconnected pores having substantially uniform pore size distribution; said microspheres having a total concentration of silanol groups from about 6 to about 16 mu mol/m . The material may be reacted with a silanizing agent to generate a completely silanized surface.