6,7-DIHYDRO-5H-PYRIDO[2,3-C]PYRIDAZINE DERIVATIVES AND RELATED COMPOUNDS AS BCL-XL PROTEIN INHIBITORS AND PRO-APOPTOTIC AGENTS FOR TREATING CANCER

Present invention relates to 6,7-dihydro-5H-pyrido[2,3- c]pyridazine, 1,2,3,4-tetrahydroquinoline, 1H-indole, 3,4- dihydro-2H-1,4-benzoxazine, 1H-pyrrolo[2,3-b]pyridin-1-yl, 7H- pyrrolo[2,3-c]pyridazine, 5H,6H,7H,8H,9H-pyridazino[3,4-b]azepine derivatives of formula (IA), (IA) pharmaceutical composi...

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Bibliographische Detailangaben
Hauptverfasser:	MARAGNO, Ana Leticia, SANDERS, Emma, TIMÁRI, Mátyás Pál, MURRAY, James Brooke, CHANRION, Maïa, STARCK, Jerome-Benoit, DAVIDSON, James Edward Paul, COLLAND, Frédéric, HERNER, András, DODSWORTH, Mark Philip, BEDFORD, Simon, NOVÁK, Tibor, PACZAL, Attila, KOTSCHY, András, WEBB, Paul
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Present invention relates to 6,7-dihydro-5H-pyrido[2,3- c]pyridazine, 1,2,3,4-tetrahydroquinoline, 1H-indole, 3,4- dihydro-2H-1,4-benzoxazine, 1H-pyrrolo[2,3-b]pyridin-1-yl, 7H- pyrrolo[2,3-c]pyridazine, 5H,6H,7H,8H,9H-pyridazino[3,4-b]azepine derivatives of formula (IA), (IA) pharmaceutical compositions containing them, and their usage as pro-apoptotic agents for the treatment of cancer, and immune and autoimmune diseases. s