AGONIST DR5 BINDING POLYPEPTIDES

AGONIST DR5 BINDING POLYPEPTIDES

There are represented isolated polypeptides ac¬ting for DR5 receptors as ligand (TRAIL) agonists inducing apoptosis. Said polypeptides contain three, four or five monomeric subunits of singular variable domains characterized accordingly amino acid sequ¬en¬ces. They are applied at the treatment of di...

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Bibliographische Detailangaben
Hauptverfasser: STOVER, David Raymond, KOLKMAN, Joost, DOMBRECHT, Bruno, ZHANG, Jingxin, CROMIE, Karen, MEERSCHAERT, Kris, LI, Jing, ETTENBERG, Seth
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:There are represented isolated polypeptides ac¬ting for DR5 receptors as ligand (TRAIL) agonists inducing apoptosis. Said polypeptides contain three, four or five monomeric subunits of singular variable domains characterized accordingly amino acid sequ¬en¬ces. They are applied at the treatment of diseases associated with the DR5, particularly various types of tumors. 9 dependent