Triamide-Substituted Indoles, Benzofuranes and Benzothiophenes as Inhibitors of Microsomal Triglyceride Transfer Protein (MTP) and/or Apolipoprotein B (Apo B) Secretion

Triamide-Substituted Indoles, Benzofuranes and Benzothiophenes as Inhibitors of Microsomal Triglyceride Transfer Protein (MTP) and/or Apolipoprotein B (Apo B) Secretion

1. Technical Result Reduce of cholesterol and triglycerides level. 2. Essence Compounds of formula (1): (values of R1, R2, R3, R4, R5, R6, R7, R8, n and m are defined in the description) or pharmaceutically acceptable salt, method for its production, pharmaceutical composition containing it and use...

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Hauptverfasser: Bronk (US), Brian, Scott, Mason (GB), Clive, Philip, Li(CN), Jin, Bertinato (US), Peter, Huatan (GB), Hiep, Blize (US), Alan, Elwood, Cheng (CA), Hengmiao
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:1. Technical Result Reduce of cholesterol and triglycerides level. 2. Essence Compounds of formula (1): (values of R1, R2, R3, R4, R5, R6, R7, R8, n and m are defined in the description) or pharmaceutically acceptable salt, method for its production, pharmaceutical composition containing it and use thereof for the treatment of obesity and lipid disorders in animals. 3. Field of Application Medicine. Figura: 6