METHOD OF PRODUCING DERIVATIVE OF QUINOLINE OR ITS PHARMACEUTICALLY ACCEPTABLE ESTER, OR THEIR SALTS

Invention refers to heterogeneous ring compounds, in particular to reception derivatives of quinoline of the formula: wherein Z is an amino group or a halogen atom, in which R1 is a hydrogen atom, a lower alkyl or haloalkyl group, R2 is a hydrogen atom or a lower alkyl group, R3 is a lower alkyl or haloalkyl group, R4 is a hydrogen atom or a lower alkyl group, R5 and R6 are the same or different and each represents a hydrogen atom or a lower alkyl group, or R5 and R6, together with the nitrogen atom to which they are attached, form a heterocyclic ring, and n is 0 or 1, with the proviso that when Z is an amino group R is (B); and esters thereof and salts thereof and processes for preparation thereof. These compounds show excellent antbacterial activity and are useful antibacterial agents. The purpose of the invention is the reception of new more active compounds. Their reception is conducted from corresponding derivatives of quinoline and piperazine, and if it is necessary, the compound is converted in pharmaceutically acceptable salt, or its pharmaceutically acceptable ester or pharmaceutically acceptable salt of ester. 2 Tables