METHOD OF PRODUCING DERIVATIVES OF QUINOLINE OR THEIR PHARMACEUTICALLY ACCEPTABLE ESTERS OR ACID-ADDITIVE SALTS

The invention concerns derivatives of quinoline, in particular production of compounds of the general formula where A - halogen or N-CH2-CHR2-NR1CHR3-CHR4 R1 - hydrogen, group of methyl or ethyl, R2 - hydrogen, group of methyl or group of fluorine methyl, R3 and R4 - are identical or different, hydrogen or methyl group, or pharmaceutically acceptable salts thereof, for example the additive salts of an acid displaying antibacterial activity that can be used in medicine. The purpose of the invention is the creation of new more active materials of said class. Synthesis is conducted by the reaction of ammonia with compounds of formula I where the carboxyl is substituted by Y-H or the lowest alkyl, and instead of NH2 there is a halogen. If necessary the obtained compound is hydrolyzed in an acid. The final product is isolated in the form of an acid or in the form of the necessary salt. New compounds are low toxic - ЛД50 more than 2000 mg/kg also have greater than known substances, activity. 5 Tables.