New derivatives of 5-amino-isoindoline

The invention comprises 5-amino isoindolines of the general formula wherein R1 is a hydrogen atom and R11 is a COR111 group, R111 being a hydrogen atom or an aliphatic, araliphatic, aromatic, or heterocyclic radical; or R1 is a COR111 group and R11 is a hydrogen atom a COR111 group or an aliphatic radical; salts thereof with physiologically acceptable acids and the preparation of such compounds when R is a hydrogen atom and R11 is a COR11 group, by acylating 5 -nitro-isoindoline and reducing the aromatic nitro group; when R1 is a COR111 group and R11 is a hydrogen atom, by providing the heterocyclic nitrogen atom with a protective grouping, acylating the 5-amino group and then removing the protective group; when R1 is COR111 and R11 is an aliphatic radical, by acylating a 5-amino isoindoline bearing an aliphatic radical in the 2-position; and when both R1 and R11 are both COR111 radicals, by acylating 5-amino-isoindoline.ALSO:Pharmaceutical compositions having analgesic, antipyretic and antiphlogistic properties comprise compounds of the formula and their salts with physiologically acceptable acids, either alone or in admixture with known analgesic, antipyretic and/or antiphlogistic compounds (whereby such mixtures can also exhibit synergism). The compositions may be in the form of solutions for parenteral or dropwise administration, tablets or dragees.