Control of cylinders of an engine according to an engine configuration scheme

An engine optimization controller may determine values of a set of input parameters of an engine and process, using an engine model, the values to determine a plurality of sets of potential output parameters. The engine optimization controller may determine, based on the plurality of sets of potential output parameters, an engine optimization scheme, which may indicate a first number of cylinders, of one or more cylinders of the engine, to be active and to receive gas; a second number of cylinders, of the one or more cylinders, to be inactive and to receive gas, and/or a third number of cylinders, of the one or more cylinders, to be inactive and to not receive gas. The engine optimization controller may provide the engine configuration scheme to another controller to allow control of the one or more cylinders and one or more fuel injectors according to the engine configuration scheme.